UMAMI Bioworks is the leading bioplatform for the development and production of sustainable blue biosolutions. Through the synthesis of machine learning, multi-omics biomarkers, and digital twins, UMAMI has established market-leading capability for discovery and development of cultivated blue bioproducts and services serving industries from human food to cosmetics to pet nutrition.

By partnering with market leaders as their biomanufacturing solution provider, UMAMI is democratizing access to sustainable blue bioeconomy solutions that address a wide range of global challenges.

We’re a venture-backed biotech company located in Singapore where some of the world’s smartest, most passionate people are pioneering a sustainable food future that is attractive and accessible to people around the world. We are united by our collective drive to ask tough questions, take on challenging problems, and apply cutting-edge science and engineering to create a better future for humanity. At Umami Bioworks, you will be encouraged to dream big and will have the freedom to create, invent, and do the best, most impactful work of your career.

Umami Bioworks is looking to hire an inquisitive, innovative, and independent Scientist for Bioprocess Development to join our R&D team in India. 

Overview

The candidate will be responsible for leading the process development of cultivated fish cell culture scale-up, from static and small-scale dynamic culture to 500+ L. This will require experimental design, wet-lab work, and data analysis for cell proliferation at increasing scale. Successful candidates will be expected to drive upstream process development activities, develop and clearly communicate requirements to inputs teams, and will bring expertise in operating scale-down bioreactors, developing optimized bioprocesses, and scaling process from bench to pilot.

Key Responsibilities

• Design and set up a bioreactor lab, including coordinating with vendors to qualify and procure bioreactors and supporting equipment.

• Perform experimental screening of bioprocess approaches at bench-scale to establish optimal processes and operating modes in line with future commercialization targets

• Develop robust, iterative scale-down processes to maximize yield and process efficiency at benchtop (<10L) scale

• Define key process parameters for scale-up and develop analytical methods for continuous process

  monitoring and control

• Collaborate with other teams and members of the bioprocess group on the development and implementation of robust and scalable bioprocesses for pilot production and technology transfer for GMP manufacturing

• Align with senior leadership to implement critical decisions

• Lead co-development partnerships to drive shared process development goals

• Conduct rigorous experimental design, documentation, and data analysis

• Provide concise and effective reporting on project deliverables and presentation of data

• Evaluate processes and assumptions for potential improvements to efficiency and manufacturability, providing creative solutions to challenging technical problems

Core Competencies & Skills

• Proficiency with Design of Experiments (DOE) methodology for bioprocess development, including

  experiment design and data analysis

• Proficiency in engineering techniques, including quantitative modeling and mass balance

• Basic scripting in relevant languages such as Python, R, SQL, etc.

• Familiarity with mammalian metabolic pathways and proficiency in metabolic flux analysis is a plus

• Understanding of a range of analytical chemistry techniques necessary to support process development

• Ability to work in a fast-paced, dynamic environment and skills to prioritize and deliver against timelines

• Strong troubleshooting and problem-solving skills

• Excellent written and verbal communication skills, including strong command of the English language

Qualifications & Experience

• M.S. or PhD in a relevant field (Bioengineering, Chemical Engineering, Cell Biology, or equivalent

• 5+ years of industry experience (MS) or 3+ years of industry experience (PhD) in biotechnology, cell manufacturing or a relevant engineering field

• 2+ years of direct experience in lab to mid-scale (50-500L) animal cell culture in a process development environment

• Experience with batch and fed-batch cell culture is essential; intensified or continuous process experience is a plus

• Tech transfer experience is preferred

• Experience with scale-down model development, predictive modeling, and model validation is a plus

• Experience with high throughput bioreactor systems and automation is a plus

• Track record of successfully leading small teams is strongly preferred

• Strong track record of peer-reviewed publications is preferred

• Demonstrated scientific rigor toward continuous improvement

You will work directly with other members of our small but growing team to do cutting-edge science and will have the autonomy to test new ideas and identify better ways to do things.